Preheat oven to 350 degrees. Lightly grease a loaf pan of 8 in baking dish.
In a bowl, combine ground beef, bread crumbs, eggs, garlic powder, and Worcestershire sauce. Mix until everything is combined. Form meat into a loaf and place in dish.
Bake for 30 minutes.
While baking, whisk ketchup, brown sugar and pineapple until smooth.
Spread over meat and bake for another 15-20 minutes or until cooked thoroughly.